Water Based vs. Silicone: Best Lubricant for Sensitive Skin Sliquid Using lube is a normal and healthy part of being sexually active, but the different options can be daunting. Here's a quick guide to the pros and cons of the most common Wetter is Better: Global Protection Corp.'s Guide to Lube Global Protection Corp. Jill A quick run down on personal lubricants. . Remember, lubricants are usually used with sex, while vaginal moisturizers are used 2 3 times per week routinely. Some lubricants may also be used 7 Facts on What People Really Want to Know About Silicone Based Lube ONE