Can Disposable Vapes Set Off Smoke Alarms Smoke Detectors & Fire Alarms Does Vaping Set Off Smoke Alarms? Sometimes when people vape for the first time they can feel quite unwell and, in some cases, they can actually be sick. This is due to the nicotine they're ingesting and is Electronic Cigarettes American Nonsmokers' Rights Foundation no smoke .org Secondhand Vape Exposure: Effects, Who's at Risk, and More Secondhand vape plumes could form lung damaging radicals American Chemical Society